Indications

Magnide is indicated for the treatment of following condition:

• Relieving the symptoms of magnesium deficiency
• Heart and vascular system: Heartbeat acceleration, heartbeat irregularities, heart attack, angina pectoris, mild severe hypertension
• Nerve and muscles: Sudden and excess spasm in muscle (tetani), spasm formation in muscle, stomach-intestine cramps, increased stimulability of muscle and nerves, calf cramps, cases with cramps and stress in new-born or small children
• Gynecological diseases, related to birth and baby: Preterm spasms, cervical failure, early membrane rupture, spasm in pregnancy (eclampsia/pre-eclampsia, tocolysis necessary to use betamimetic), menstrual period with pain
• Orthopedics: Calcification and ossifications
• Prevention of renal calculus formation: Prevention of renal calculus formation (prevention of repetition of calcium oxalate urolithiasis)
• Treatment of diabetic and migraine (a type of headache)

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Pharmacology

Magnesium is one of the most common minerals on earth and is present in many foods. Magnesium oxide is a mineral supplement used to treat or prevent low levels of magnesium in the blood. It’s essential for human health and is used over 600 cellular reactions throughout the body. In fact, every cell and organ need this mineral to function properly. It contributes to bone health, as well as proper brain, heart and muscle function.

Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing the amount of acetylcholine liberated at the end plate by the motor nerve impulse. Magnesium is said to have a depressant effect on the central nervous system (CNS), but it does not adversely affect the woman, fetus or neonate when used as directed in eclampsia or pre-eclampsia.

Approximately 24-76% of ingested magnesium is absorbed in the gastrointestinal tract, primarily via passive par cellular absorption in the small intestine. 20% of the magnesium found in human serum is protein bound. Approximately 60-70% of this fraction is bound to albumin while the remainder is bound to globulin proteins. Magnesium has the ability to bind to 3751 human proteins. Magnesium does not appear to be metabolized. The majority of magnesium is excreted renally.

Dosage & Administration

Recommended daily dose for patient over 12 years of age is 1-2 tablet. If a dose of Magnesium Oxide is missed take it as soon as remember, unless it's almost time for the next dose. In that case, skip the missed dose and continue on regular medication schedule. Do not double up on doses to make up for a missed dose.

Kidney failure: Do not take this medication in the patient with severe kidney failure.
Liver failure: There is no data about usage in the patients with liver failure.

* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন'

Interaction

Other drugs may affect the treatment with this medicine. Before taking Magnide, talk to doctor if taking-

• Muscle relaxant drugs (non-depolarize neuromuscular blockers)
• Some antibiotic (amino quinolones, nitrofurantoin, penisilamine, tetracyclines, fluoroquinolones)
• Digoxin (heart failure treatment)
• Lithium (change of emotion and control of depression state)
• Sodium polystyrene sulfonate (provides elimination of potassium)
• Cellulose sodium phosphate (used to prevent kidney stones)
• Other medicines containing magnesium (including magnesium enemas)
• Barbiturate (drugs used for the treatment of sleeplessness), opioids (substances acting as morphine), hypnotics (somnific drugs)
• Nifedipine (drugs used in hypertension or heart problems)
• The absorption of levothyroxine containing drugs which are used in the treatment of thyroid diseases, is impaired when used concomitantly, therefore at least 4 hours interval is required between the uses of these two drugs.

Contraindications

• Do not take this drug without first talking to your doctor if you have kidney disease.
• Before taking this drug, tell your doctor if you have any other medical conditions, allergies, or if you take other medicines or other herbal/health supplements. This drug may not be recommended in some situations.
• It is not known whether this drug will harm an unborn baby.
• Do not take this drug without first talking to your doctor if you are pregnant or planning a pregnancy. It is not known whether, this drug will harm a nursing baby.
• Do not take this drug without first talking to your doctor if you are breast-feeding a baby.

Side Effects

Common side effects include: Diarrhea, Cramping.

Serious side effects include: Itching, Rash or hives, Mood or mental changes, Lightheadedness or dizziness, Weakness, Unusual fatigue, Nausea, Vomiting. Consult with doctor immediately if any of this occurs.

Pregnancy & Lactation

Do not use it without consulting with doctor during pregnancy. Do not use it without consulting doctor during breastfeeding.

Precautions & Warnings

• Do not take more magnesium than doctor or the product label recom mends. Too much magnesium in the blood can cause serious side effects.
• Before taking Magnide, consult with doctor whether allergic to it, antacids, laxatives, or any other drugs.
• Should not use this supplement as antacid for longer than two weeks, or as a laxative for longer than one week, unless doctor tells to do so.
• Before taking the supplement, tell physician if have or have ever had liver, kidney, heart, or intestinal disease. Should also tell health care provider if have or have ever had high blood pressure, or on any kind of special diet.
• Should take other medications either two hours before or two hours after taking Magnide.

Therapeutic Class

Antacids, Electrolytes preparations, Oral electrolytes preparations

Storage Conditions

Store below 25°C. Protected from light and moisture. Keep all medicines out of the reach of children.