Indications

DHEA has been shown to enhance fertility in women of advanced ovarian age as DHEA increases egg and embryo count. DHEA Tablets may be a useful nutritional adjunct for individuals who wish to support the body’s normal DHEA functions.

Heart disease, Stress, Cancer, Immune deficiency, Mental functions like loss of memory, Alzheimer’s condition etc., Obesity, Aging, Inflammatory balance, Hormonal balance, Mood regulation, Bone health like osteoporosis, Cardiovascular disease, Diabetes, Depression, Erectile dysfunction, Adrenal insufficiency, Systemic Lupus Erythematosus (SLE), Allergic disorder.

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Pharmacology

DHEA, dehydroepiandrosterone, is the most abundant adrenal steroid hormone in the body. After it is made by the adrenal glands, it travels into cells throughout the body where it is converted into androgens, estrogens and other hormones. These hormones regulate fat and mineral metabolism, endocrine and reproductive function, and energy levels. The amount of each hormone to which DHEA converts to depends on an individual’s
biochemistry, age, and sex. DHEA levels peak around age 25 and then decline steadily. DHEA is produced endogenously in the human body by the adrenal gland, liver, and minute amounts in the brain. In men DHEA is also produced in the testes. DHEA is metabolized to androstenedione, which is the major precursor of estrogens and androgens. DHEA changes the ratio of circulating androgens and estrogens. In women supplementation with DHEA seems to significantly increase circulating androgens, but not as much an increase in estrogens in women. In men supplementation significantly increases circulating estrogens while a smaller amount of androgen increase is seen. The androgen and estrogen effects may be responsible for the benefits of DHEA. In the brain, DHEA is concentrated in the limbic regions and may act as an excitatory neuroregulator, which antagonizes GABA transmission. DHEA supplementation may also inhibit thromboxane A2 synthesis in platelets, increase IGF-1, increase cGMP, and nitric oxide synthesis, which may have beneficial effects on cardiovascular risk.

Dosage & Administration

Adrenal insufficiency: 50 mg/day for 3 months is considered a replacement dose, while 200 mg/day achieves supraphysiological circulating levels and is considered a pharmacological dose.

Anorexia nervosa: 100 mg/day for 6 months was used in a pilot study.

Diminished ovarian reserve: 50 to 75 mg/day (in divided doses) has been used in clinical studies of assisted reproduction.

Exercise training–induced muscle damage: 100 mg/day of Dehydroepiandrosterone supplementation was administered over 5 days in a study in young men undergoing exercise training.

Major depressive disorder: Doses ranging from 30 to 450 mg/day for 6 to 8 weeks have been used in clinical studies.

Metabolic syndrome: 100 mg/day for 3 months has been used in a study evaluating effects against metabolic syndrome in pre-and postmenopausal women.

Postmenopausal women: 25 mg/day has been suggested because this dose minimizes androgenic adverse effects; however, only studies in which at least 50 mg/day was used demonstrated positive outcomes as hormonal replacement therapy.

Use in children & adolescents: Not for use by individuals under the age of 18 years.

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Interaction

With Medicine: Because calcium channel blockers may increase DHEA levels in some individuals, concurrent DHEA supplementation is not recommended unless closely monitored by a health professional.

• Glucocorticoids: these drugs can suppress endogenous DHEA production
• Insulin: insulin can decrease endogenous DHEA-S
• Triazolam: DHEA can increase plasma levels of triazolam
• Drugs metabolized through CYP3A: DHEA inhibits CYP 3A

With food & others:

• Diabetes: DHEA can increase insulin sensitivity
• Hormone sensitive cancers: DHEA has estrogenic like effects
• Liver dysfunction: DHEA can exacerbate liver dysfunction

Contraindications

DHEA is contraindicated in patients with history of psychiatric disease, history of mania, and bipolar disorder, this is due to an increase risk of mania. It is also contraindicated in patients with hormone sensitive cancers due to its estrogen effects.

Side Effects

Common: Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen.

Rare: Discontinue use and call a physician or licensed qualified health professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Pregnancy & Lactation

Do not use if pregnant & nursing.

Precautions & Warnings

• Consult a physician or licensed qualified health professional before using DHEA if you have, or have a family history of breast cancer, prostate cancer, prostate enlargement, heart disease, low 'good' cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.
• Individuals with hypertension should avoid DHEA.
• Individuals with thyroid disorder or those using thyroid hormone may require monitoring.
• Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects.

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.